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Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Cui, B; Johnson, S P; Bullock, N; Ali-Osman, F; Bigner, D D; Friedman, H S.
Affiliation
  • Cui B; Departments of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Mol Pharmacol ; 75(6): 1356-63, 2009 Jun.
Article in En | MEDLINE | ID: mdl-19261750

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Carmustine / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Antineoplastic Agents, Alkylating / DNA Mismatch Repair Limits: Humans Language: En Journal: Mol Pharmacol Year: 2009 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Carmustine / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Antineoplastic Agents, Alkylating / DNA Mismatch Repair Limits: Humans Language: En Journal: Mol Pharmacol Year: 2009 Document type: Article Affiliation country: