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In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions.
Thelingwani, Roslyn S; Zvada, Simbarashe P; Dolgos, Hugues; Ungell, Anna-Lena B; Masimirembwa, Collen M.
Affiliation
  • Thelingwani RS; Department of Drug Metabolism and Pharmacokinetics/PD and Toxicology, African Institute of Biomedical Science and Technology, Harare, Zimbabwe.
Drug Metab Dispos ; 37(6): 1286-94, 2009 Jun.
Article in En | MEDLINE | ID: mdl-19299526
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiabendazole / Microsomes, Liver / Drug Interactions / Enzyme Inhibitors / Cytochrome P-450 CYP1A2 Inhibitors Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2009 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiabendazole / Microsomes, Liver / Drug Interactions / Enzyme Inhibitors / Cytochrome P-450 CYP1A2 Inhibitors Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2009 Document type: Article Affiliation country: