Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages.
Leuk Res
; 34(1): 63-8, 2010 Jan.
Article
in En
| MEDLINE
| ID: mdl-19406473
ABSTRACT
Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN. All patients with gain of REL were unmutated for IGHV (p=0.03). Gain of MYCN was associated with increased mRNA expression (p=0.005), suggesting a pathogenic role for MYCN. Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 2
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Chromosome Aberrations
Limits:
Humans
Language:
En
Journal:
Leuk Res
Year:
2010
Document type:
Article
Affiliation country: