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1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.
Miller-Moslin, Karen; Peukert, Stefan; Jain, Rishi K; McEwan, Michael A; Karki, Rajesh; Llamas, Luis; Yusuff, Naeem; He, Feng; Li, Yanhong; Sun, Yingchuan; Dai, Miao; Perez, Lawrence; Michael, Walter; Sheng, Tao; Lei, Huangshu; Zhang, Rui; Williams, Juliet; Bourret, Aaron; Ramamurthy, Arun; Yuan, Jing; Guo, Ribo; Matsumoto, Melissa; Vattay, Anthony; Maniara, Wieslawa; Amaral, Adam; Dorsch, Marion; Kelleher, Joseph F.
Affiliation
  • Miller-Moslin K; Department of Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 01239, USA. karen.miller@novartis.com
J Med Chem ; 52(13): 3954-68, 2009 Jul 09.
Article in En | MEDLINE | ID: mdl-19469545
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalazines / Receptors, G-Protein-Coupled / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2009 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalazines / Receptors, G-Protein-Coupled / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2009 Document type: Article Affiliation country: