Breast cancer and pregnancy: how safe is trastuzumab?
Nat Rev Clin Oncol
; 6(6): 367-70, 2009 Jun.
Article
in En
| MEDLINE
| ID: mdl-19483741
ABSTRACT
BACKGROUND:
A 29-year-old woman was diagnosed with lymph-node-positive, steroid-hormone-receptor-negative and HER2/neu-positive breast cancer. She underwent surgery followed by cyclophosphamide, epirubicin, and 5-fluorouracil chemotherapy, and received radiotherapy followed by trastuzumab therapy for 1 year. During the tenth month of trastuzumab therapy, the patient reported a missed period and had a positive pregnancy test. INVESTIGATIONS Physical examination, pregnancy test, echocardiography. DIAGNOSIS Unintended pregnancy during adjuvant trastuzumab therapy. MANAGEMENT Cessation of trastuzumab and close monitoring of mother and fetus during pregnancy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications, Neoplastic
/
Breast Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Nat Rev Clin Oncol
Journal subject:
NEOPLASIAS
Year:
2009
Document type:
Article
Affiliation country: