In situ gelling polymers in ocular drug delivery systems: a review.
Crit Rev Ther Drug Carrier Syst
; 26(1): 85-118, 2009.
Article
in En
| MEDLINE
| ID: mdl-19496748
ABSTRACT
The review article aims to highlight the recent developments in various in situ gel-forming polymeric systems that are used to achieve prolonged contact time of drugs with the cornea and increase their ocular bioavailability. These phase-change polymers, which trigger the drug release in response to external stimuli, are the most investigated in controlled drug delivery. The present review summarizes in detail these various polymers, which undergo sol-gel transition due to physical (temperature) or chemical (pH, ions) stimuli when instilled in the eye. As a whole, this article provides valuable insight into current trends in the field of in situ gel-forming ocular drug delivery systems.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymers
/
Pharmaceutical Preparations
/
Drug Delivery Systems
Limits:
Animals
/
Humans
Language:
En
Journal:
Crit Rev Ther Drug Carrier Syst
Journal subject:
TERAPIA POR MEDICAMENTOS
Year:
2009
Document type:
Article
Affiliation country: