Modulation of malaria-induced immunopathology by concurrent gastrointestinal nematode infection in mice.
Int J Parasitol
; 39(14): 1525-32, 2009 Dec.
Article
in En
| MEDLINE
| ID: mdl-19716371
ABSTRACT
We investigated malaria-associated pathology in mice co-infected with Heligmosomoides polygyrus (Hp) and Plasmodium chabaudi AS (Pc). Despite higher peak parasitemia, co-infected wild-type (WT) C57BL/6 mice displayed similar body weight losses, malarial anaemia, and tissue damage but less severe hypothermia and hypoglycaemia, and earlier reticulocytosis than Pc-infected WT mice. Co-infected STAT6(-/-) mice, deficient in nematode-induced Th2 responses, experienced similar peak parasitemias and generally suffered malaria-associated pathology to a similar degree as co-infected WT mice. These data indicate a complex relationship amongst helminths, malaria and host immune responses resulting in modulation of some but not all aspects of malaria-associated pathology.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nematospiroides dubius
/
Plasmodium chabaudi
/
Strongylida Infections
/
Parasitemia
/
Malaria
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Int J Parasitol
Year:
2009
Document type:
Article
Affiliation country: