[BRCA1- and BRCA2- associated breast carcinomas]. / BRCA1- und BRCA2-assoziierte Mammakarzinome.
Pathologe
; 30 Suppl 2: 207-9, 2009 Dec.
Article
in De
| MEDLINE
| ID: mdl-19795125
ABSTRACT
Breast cancers with a genetic BRCA1-/BRCA2 background differ from each other and sporadic cases. A specific pathological surrogate marker, however, does not exist. In this study the results of a German reference centre are reported. BRCA1 associated cancers are predominantly high grade (G3), triple negative, highly proliferative (median Ki-67 55%) and only exceptionally accompanied by lobular intraepithelial neoplasia. Cancers with a BRCA2 germ line mutation are less frequent and resemble sporadic cases with a comparably higher proliferative activity and a lack of Her2 overexpression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
BRCA1 Protein
/
BRCA2 Protein
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
De
Journal:
Pathologe
Year:
2009
Document type:
Article