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Glycemic index, glycemic load, and the risk of acute myocardial infarction in Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Mursu, J; Virtanen, J K; Rissanen, T H; Tuomainen, T-P; Nykänen, I; Laukkanen, J A; Kortelainen, R; Voutilainen, S.
Affiliation
  • Mursu J; Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland. jaakko.mursu@uku.fi
Nutr Metab Cardiovasc Dis ; 21(2): 144-9, 2011 Feb.
Article in En | MEDLINE | ID: mdl-19836217
BACKGROUND AND AIM: The role of dietary glycemic index (GI) and glycemic load (GL) in coronary heart disease (CHD) is unclear. Our aim was to study the association between the dietary GI and GL and the risk of acute myocardial infarction (AMI). METHODS AND RESULTS: The study population consisted of 1981 Finnish men from the prospective population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study, aged 42-60 years and free of CHD at baseline. During an average follow-up time of 16.1 years, 376 new AMI events occurred. In multivariable-adjusted Cox proportional hazards models, the relative risk (RR) for AMI in the highest quartile of GI was 1.25 (95% CI: 0.92-1.69; P for trend=0.08) and for GL 1.11 (95% CI: 0.79-1.57; P for trend=0.21) when compared with the lowest quartile. For overweight (BMI ≥ 27.5 kg/m²) men, the multivariable-adjusted RR for AMI in the highest compared to the lowest tertile of GI and GL were 1.58 (95% CI: 1.03-2.43; P for trend=0.04, P for interaction=0.01) and 2.05 (95% CI: 1.30-3.23; P for trend=0.002, P for interaction=0.002), respectively. For physically less active men; energy expenditure for leisure-time physical activity < 50 kcal/d, the RR for AMI was 1.72 (95% CI: 1.07-2.76; P for trend=0.04, P for interaction 0.80) with higher GL. CONCLUSIONS: Our results suggest that both high dietary GI and GL are associated with increased risk of AMI among overweight and GL possibly among less physically active men.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dietary Carbohydrates / Glycemic Index / Diet / Myocardial Infarction Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Nutr Metab Cardiovasc Dis Journal subject: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Year: 2011 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dietary Carbohydrates / Glycemic Index / Diet / Myocardial Infarction Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Nutr Metab Cardiovasc Dis Journal subject: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Year: 2011 Document type: Article Affiliation country: Country of publication: