Asymmetric conjugate reductions of coumarins. A new route to tolterodine and related coumarin derivatives.
Org Lett
; 11(23): 5374-7, 2009 Dec 03.
Article
in En
| MEDLINE
| ID: mdl-19877705
ABSTRACT
The combination of catalytic amounts of [(R)-DTBM-SEGPHOS]CuH in the presence of stoichiometric DEMS (diethoxymethylsilane) in toluene at room temperature leads to asymmetric reductions of 4-substituted coumarins. Several targets or their known precursors can be prepared in high yields and ee's, including the muscarine receptor antagonist (R)-tolterodine.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylpropanolamine
/
Benzhydryl Compounds
/
Coumarins
/
Cresols
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2009
Document type:
Article
Affiliation country: