A review of transcriptomics in cutaneous chemical exposure.
Cutan Ocul Toxicol
; 28(4): 157-70, 2009.
Article
in En
| MEDLINE
| ID: mdl-19888885
ABSTRACT
Monitoring gene expression profiles in the skin using microarrays has become a useful approach to enhance the understanding of dermal function, toxicologic mechanisms, and risk assessment. With respect to cutaneous chemical exposure, there are few transcriptomic studies in the published literature, and these often differ in experimental design and availability of raw data. An assessment of multiple microarray data sets could be advantageous for identifying potential redundant biological mechanisms or genes associated with dermal responses to chemical exposure. As in vivo cutaneous chemical exposure models can vary, extrapolations from analyzing multiple cross-species microarray data sets could aid in identifying a general set of pathways or genes that could guide future study direction and evaluation of dermal toxicologic assessments and potential therapeutic intervention. This review provides a summary of studies in the open literature that utilize transcriptomics in assessing the molecular responses in chemical-exposed skin with an intent of determining whether biomarkers could be identified and the potential for future meta-analyses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
RNA, Messenger
/
Gene Expression Regulation
/
Toxicity Tests
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
Type of study:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Animals
/
Humans
Language:
En
Journal:
Cutan Ocul Toxicol
Journal subject:
DERMATOLOGIA
/
OFTALMOLOGIA
/
TOXICOLOGIA
Year:
2009
Document type:
Article
Affiliation country: