Evidence for an involvement of the brain cholecystokinin B receptor in anxiety.
Proc Natl Acad Sci U S A
; 88(4): 1130-3, 1991 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-1996314
ABSTRACT
The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model of anxiety. The selective CCK-B receptor antagonists CI-988 (PD 134308) and L-365,260 produced anxiolytic-like effects, whereas MK-329, a CCK-A receptor antagonist, was respectively less potent by factors of 313 and 200. The intracerebroventricular administration of the nonselective CCK receptor agonist caerulein or the selective CCK-B receptor agonist pentagastrin increased dose dependently the level of anxiety. CI-988 dose dependently antagonized the anxiogenic response to pentagastrin but not that induced by pentylenetetrazol. These results strongly suggest that activation of the brain CCK-B receptor induces anxiety and that selective antagonists of this receptor represent a separate class of anxiolytic agents.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anxiety
/
Phenylurea Compounds
/
Benzodiazepinones
/
Cholecystokinin
/
Cerebral Ventricles
/
Chlordiazepoxide
/
Receptors, Cholecystokinin
/
Indoles
/
Meglumine
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
1991
Document type:
Article
Affiliation country: