Effect of passaging on Mer phenotype of human fetal cell cultures.
Mutat Res
; 254(2): 153-60, 1991 Mar.
Article
in En
| MEDLINE
| ID: mdl-2002811
ABSTRACT
With increasing passage in culture, the human fibroblast cell strain GM11 lost the Mer+ phenotype (the ability to support the growth of adenovirus 5 damaged prior to infection by MNNG). All of 46 embryonic strains prepared either from various organs of 20 fetuses from 6-7 to 13-14 weeks of gestational age or from two hydatidiform moles showed normal repair of MNNG-treated virus. We conclude that human fetal strains are not usually deficient in such repair, and that the behavior of GM11 is atypical.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cells, Cultured
/
DNA Repair
/
Mutation
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Mutat Res
Year:
1991
Document type:
Article
Affiliation country: