PDGF and vessel maturation.
Recent Results Cancer Res
; 180: 103-14, 2010.
Article
in En
| MEDLINE
| ID: mdl-20033380
ABSTRACT
Pericytes are smooth muscle-like cells found in close contact with the endothelium in capillaries, where they regulate the morphology and function of the vessels. During vessel formation, platelet-derived growth factor-BB (PDGF-BB) is required for the recruitment and differentiation of pericytes. Tumor vessels display abnormal morphology and increased endothelial proliferation, resulting in leaky, tortuous vessels that are often poorly perfused. These vessels typically display decreased pericyte density, and the tumor-associated pericytes often express abnormal markers and show abnormal morphology. Anti-angiogenic therapy targeting pro-angiogenic growth factor pathways has been applied to a broad range of solid tumors with varying results. Studies utilizing mouse models indicate that the presence of pericytes protect endothelial cells against inhibition of vascular endothelial growth factor (VEGF) signaling. Simultaneous inhibition of PDGF receptors on pericytes therefore improves the effect of VEGF inhibitors on endothelial cells and enhances anti-angiogenic therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Platelet-Derived Growth Factor
/
Neovascularization, Physiologic
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Recent Results Cancer Res
Year:
2010
Document type:
Article
Affiliation country: