Chemzymes: a new class of structurally rigid tricyclic amphibian organocatalyst inspired by natural product.
Org Lett
; 12(6): 1220-3, 2010 Mar 19.
Article
in En
| MEDLINE
| ID: mdl-20158252
ABSTRACT
A new class of structurally rigid tricyclic amphibian chiral catalyst was rationally designed based on the hexahydropyrrolo[2,3-b]indole skeleton as a new type of chemzyme. This new type of chemzyme possesses a structurally rigid tricyclic skeleton and a chiral pocket which provides a well-organized chiral environment for asymmetric induction, as well as a hydrophobic pocket to enable organocatalytic reactions to proceed smoothly both in organic solvents and in water.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrroles
/
Biological Products
/
Drug Design
/
Indoles
Limits:
Animals
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2010
Document type:
Article