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Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.
Xu, Ruo; Cole, David; Asberom, Ted; Bara, Tom; Bennett, Chad; Burnett, Duane A; Clader, John; Domalski, Martin; Greenlee, William; Hyde, Lynn; Josien, Hubert; Li, Hongmei; McBriar, Mark; McKittrick, Brian; McPhail, Andrew T; Pissarnitski, Dmitri; Qiang, Li; Rajagopalan, Murali; Sasikumar, Thavalakulamgar; Su, Jing; Tang, Haiqun; Wu, Wen-Lian; Zhang, Lili; Zhao, Zhiqiang.
Affiliation
  • Xu R; Merck Research Laboratories, Kenilworth, NJ 07033, USA. ruo.xu@merck.com
Bioorg Med Chem Lett ; 20(8): 2591-6, 2010 Apr 15.
Article in En | MEDLINE | ID: mdl-20236824
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Receptors, Notch / Amyloid Precursor Protein Secretases Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Receptors, Notch / Amyloid Precursor Protein Secretases Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: Country of publication: