Low bone mineral density and high incidences of fractures and vitamin D deficiency in 52 pediatric cancer survivors.
Horm Res Paediatr
; 74(5): 319-27, 2010.
Article
in En
| MEDLINE
| ID: mdl-20395667
ABSTRACT
OBJECTIVE:
To evaluate bone mineral density (BMD), fractures, and vitamin D deficiency in pediatric patients in complete remission of solid tumor; and to identify risk factors for these three abnormalities. STUDYDESIGN:
Data were collected prospectively after completion of cancer treatment. Hormonal and vitamin D deficiencies were treated. The patients were evaluated again 1 year later. PATIENTS 52 consecutive patients, 30 boys and 22 girls. Among them, 21 completed the second evaluation. MEASUREMENTS A clinical examination, nutritional assessment, and laboratory workup were performed. BMD was measured by absorptiometry.RESULTS:
Calcium intake was inadequate in 75% of patients and vitamin D reserves were low in 61.5%. BMD was low at the spine in 32.7%, and at the femur in 24% of patients. Spinal and femoral BMD Z-scores correlated significantly with each other. Femoral BMD Z-score showed significant positive correlations with changes in body mass index, urinary calcium/creatinine ratio, and time since treatment completion, and a significant negative correlation with treatment duration. Fractures were noted in 10 patients but were not correlated with BMD. In the 21 re-evaluated patients, no significant improvements were found in calcium intake, vitamin D status, or BMD Z-score.CONCLUSIONS:
Survivors of childhood solid cancer have high rates of insufficient calcium intake, vitamin D deficiency, low bone mass and fractures.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin D Deficiency
/
Bone Density
/
Fractures, Bone
/
Neoplasms
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Horm Res Paediatr
Journal subject:
ENDOCRINOLOGIA
/
PEDIATRIA
Year:
2010
Document type:
Article
Affiliation country: