Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes.
Chem Commun (Camb)
; 46(39): 7379-81, 2010 Oct 21.
Article
in En
| MEDLINE
| ID: mdl-20830345
ABSTRACT
We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Cell Surface
/
Nanotubes, Carbon
/
Aptamers, Nucleotide
Limits:
Humans
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2010
Document type:
Article