Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes.
Neoplasma
; 57(6): 590-3, 2010.
Article
in En
| MEDLINE
| ID: mdl-20845998
ABSTRACT
UNLABELLED Vascularization is a prerequisite of tumor growth, invasion and metastasis. In the present work, microvessel density was assessed by quantitating using two different endothelial cell biomarkers, endoglin (CD-105) and CD-34. Fifty endocrinologically active and 36 clinically nonfunctioning pituitary adenomas, all surgically resected, as well as 10 autopsy-derived normal adenohypophyses were investigated by immunohistochemistry. The results showed that in every pituitary adenoma type endoglin, an assumed biomarker of proliferating endothelial cells, immunostained fewer vessels than CD-34 which revealed immunopositivity in all capillaries. Differences in endoglin versus CD-34 immunoexpression indicate varying degrees of vascularity in pituitary adenoma subtypes. The low levels of endoglin immunoexpression in pituitary tumors exposed to long-acting somatostatin analogs and dopamine agonists are consistent with the view that these agents inhibit angiogenesis. KEYWORDS immunohistochemistry, endoglin, CD34, microvascular density, angiogenesis, pituitary.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary Gland
/
Pituitary Neoplasms
/
Adenoma
/
Antigens, CD
/
Receptors, Cell Surface
/
Antigens, CD34
Limits:
Humans
Language:
En
Journal:
Neoplasma
Year:
2010
Document type:
Article
Affiliation country: