Diltiazem-associated photodistributed hyperpigmentation: report of two Japanese cases and published work review.
J Dermatol
; 37(9): 807-11, 2010 Sep.
Article
in En
| MEDLINE
| ID: mdl-20883365
ABSTRACT
Scherschum et al. proposed diltiazem-associated photodistributed hyperpigmentation as a novel type of drug-induced photosensitive lichenoid eruption. The characteristic clinical features were slate-gray reticulated hyperpigmentation on sun-exposed areas, while lichenoid dermatitis with prominent pigmentary incontinence was noted histologically. Although the clinical and histological features were similar to those of lichen planus pigmentosus, the histological features did not show either compact hyperkeratosis or wedge-shaped hypergranulosis, which are typical histological features of lichen planus. We describe two Japanese cases of diltiazem-associated photodistributed hyperpigmentation, who were successfully treated with topical tacrolimus, and review the published work.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Photosensitivity Disorders
/
Calcium Channel Blockers
/
Diltiazem
/
Hyperpigmentation
/
Drug Eruptions
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Limits:
Aged80
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
J Dermatol
Year:
2010
Document type:
Article
Affiliation country: