Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.
Org Biomol Chem
; 9(1): 278-90, 2011 Jan 07.
Article
in En
| MEDLINE
| ID: mdl-20976353
ABSTRACT
Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by (1)H NMR spectroscopy revealed that a C2'endo/syn conformation of the "southern" ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ribose
/
Sea Urchins
/
Receptors, Purinergic P1
/
Cyclic ADP-Ribose
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2011
Document type:
Article