Analysis of genetic deletions and duplications in the University College London bipolar disorder case control sample.
Eur J Hum Genet
; 19(5): 588-92, 2011 May.
Article
in En
| MEDLINE
| ID: mdl-21206513
ABSTRACT
Genetic deletions and duplications known as copy number variants have been strongly implicated in genetic susceptibility to schizophrenia, autism, attention deficit hyperactivity disorder and epilepsy. The overall rate of copy number variants in the University College London (UCL) bipolar disorder sample was found to be slightly lower than the rate in controls. This finding confirms the results from other studies that have also shown no increased rate of copy number variants in bipolar disorder. However, some rare duplications and deletions were observed only in bipolar disorder cases and not in controls, these included some that had previously been detected only in rare cases of bipolar disorder. We conclude that copy-number variant analysis shows no obvious sharing of the same genetic susceptibility between schizophrenia and bipolar disorder. Copy number variants do not seem to have an important role in susceptibility to bipolar disorder, they may, however, still represent a rare cause of the disease, although the evidence for this is far from clear.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bipolar Disorder
/
Genetic Predisposition to Disease
/
DNA Copy Number Variations
Type of study:
Observational_studies
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Eur J Hum Genet
Journal subject:
GENETICA MEDICA
Year:
2011
Document type:
Article
Affiliation country: