[Combination of antioxidants and a hepatoprotector in the treatment of patients with diabetic distal symmetric polyneuropathy].
Lik Sprava
; (3-4): 68-79, 2010.
Article
in Uk
| MEDLINE
| ID: mdl-21268294
ABSTRACT
The complex open randomized clinical, instrumental and biochemical research with including 89 patients with type 2 diabetes mellitus (DM), complicated with distal symmetric polyneuropathy (DDSP) has been conducted. It is proved that the antioxidant "cocktail" application (Dialipon, Byocerulin, hepatoprotector with the antioxidant action Glutargin) contributes to the improvement of different levels of antioxidant defence, reduces free radical processes intensification, improves hepatocyte state which dysfunction is one of leading links of DDSP pathogenesis. These improves indirectly and directly the peripheral nerves functional state according electroneuromyography results, prevents DDSP progression and development of diabetic foot syndrome. Taking into account negative influence of Dialipon on the clinical parameters of DDSP with parallel intensification of free radical processes at decompensated DM in the early terms of treatment, Dialipon use is recommended after normalization of glycemia. At the same time the positive influence of Byocerulin has been noted regardless the compensation state of diabetes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ceruloplasmin
/
Diabetic Neuropathies
/
Dipeptides
/
Liver
/
Antioxidants
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
Uk
Journal:
Lik Sprava
Journal subject:
MEDICINA
Year:
2010
Document type:
Article