Cellular integration and vascularisation promoted by a resorbable, particulate-leached, cross-linked poly(ε-caprolactone) scaffold.
Macromol Biosci
; 11(5): 618-27, 2011 May 12.
Article
in En
| MEDLINE
| ID: mdl-21344647
ABSTRACT
Flexible, strong scaffolds were created by crosslinking PCL with 1,6-hexamethylenediisocyanate, using paraffin beads as a porogen. Particulate leaching generated homogeneous scaffolds with interconnected spherical pores of 5-200 µm. Subcutaneous implantation in rats for 3 months resulted in minimal scaffold resorption and a non-inflammatory regenerative host response, with complete infiltration by alternatively-activated CD68(+) macrophages. In addition, scaffolds were populated extensively along microfractures by a stromal matrix, which was highly vascularised and contained a subset of stromal cells that expressed the anti-inflammatory CD163 antigen. Such microfractures may be an important physical feature for directing stromal integration and vascularisation events.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyesters
/
Neovascularization, Physiologic
/
Tissue Scaffolds
Limits:
Animals
/
Humans
Language:
En
Journal:
Macromol Biosci
Journal subject:
BIOQUIMICA
Year:
2011
Document type:
Article
Affiliation country: