Non-human leukocyte antigen antibodies reactive with endothelial cells could be involved in early loss of renal allografts.
Transplant Proc
; 43(4): 1345-8, 2011 May.
Article
in En
| MEDLINE
| ID: mdl-21620126
ABSTRACT
Preformed donor-specific human leukocyte antigen (HLA) antibodies have been associated with allograft dysfunction and failure. However, recipients of HLA-identical kidneys can develop acute humoral rejection, implicating putative pathogenic antibodies that are directed against non-HLA antigens. We investigated the presence of endothelial cell-reactive antibodies in 11 patients who experienced early loss of their transplanted kidneys owing to humoral rejection and 1 loss from renal venal thrombosis. We examined the potential efficacy of intravenous immunoglobulin to block the binding of these antibodies, as previously suggested for anti-HLA antibodies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Histocompatibility Antigens Class I
/
Kidney Transplantation
/
Endothelial Cells
/
Graft Rejection
/
Antibodies
Limits:
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Transplant Proc
Year:
2011
Document type:
Article
Affiliation country: