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Rapid HATU-mediated solution phase siRNA conjugation.
Aaronson, Jeffrey G; Klein, Lee J; Momose, Aaron A; O'Brien, Ann M; Shaw, Anthony W; Tucker, Thomas J; Yuan, Yu; Tellers, David M.
Affiliation
  • Aaronson JG; Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, Pennsylvania 19486, United States. jeffrey_aaronson@merck.com
Bioconjug Chem ; 22(8): 1723-8, 2011 Aug 17.
Article in En | MEDLINE | ID: mdl-21744777
ABSTRACT
Conditions for facile solution-phase amide conjugation of amine-modified siRNA with a diverse set of carboxylic acid partners using the coupling reagent HATU are described. These conditions eliminate the need for isolated activated esters and allow for rapid access to conjugates with a wide range of lipophilicity and functionality in good yield.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cross-Linking Reagents / RNA, Small Interfering Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2011 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cross-Linking Reagents / RNA, Small Interfering Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2011 Document type: Article Affiliation country: