[Temporal and spatial population dynamics of rabies virus isolates in China].
Bing Du Xue Bao
; 27(3): 231-7, 2011 May.
Article
in Zh
| MEDLINE
| ID: mdl-21774248
ABSTRACT
In order to study phylogeography, population dynamics and molecular evolution of rabies viruses (RABVs) isolates from China, especially spatio-temporal dynamics, the timescale of RABVs evolution and its pattern of migration, we performed an extensive comparative analysis of RABV N gene sequence data, representing 167 isolates sampled from 20 provinces in a 78-year period (from 1931 through 2009). The available Chinese isolates could be divided into two distinct cladesPhylogroup clades I comprised Chinese group 1-4; Phylogroup clades II contained Chinese group 5-8. We found no evidence for positive selection (dN/dS>1) acting at any codon and found strong selective constraints for N gene. Bayesian Markov Chain Monte Carlo (MCMC) analysis suggested that the Chinese rabies viruses originated within the last 2000 years and the mean rates of nucleotide substitution for the N gene were approximately 4 x 10(-4) substitutions per site per year. The analyses of the spatial and spatio-temporal evolution indicated that RABV isolates from China migrated among different Provinces.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rabies virus
Type of study:
Health_economic_evaluation
Country/Region as subject:
Asia
Language:
Zh
Journal:
Bing Du Xue Bao
Journal subject:
VIROLOGIA
Year:
2011
Document type:
Article
Affiliation country: