Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics.
J Am Chem Soc
; 133(32): 12350-3, 2011 Aug 17.
Article
in En
| MEDLINE
| ID: mdl-21780756
Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/ß-turn/sheet motif.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrroles
/
Pyrrolidines
/
Peptidomimetics
Language:
En
Journal:
J Am Chem Soc
Year:
2011
Document type:
Article
Affiliation country:
Country of publication: