Haploidentical allogeneic haematopoietic stem cell transplantation as salvage therapy for engraftment failure after unrelated and autologous stem cell transplantation: a case report and review of the literature.
J Int Med Res
; 39(3): 950-9, 2011.
Article
in En
| MEDLINE
| ID: mdl-21819729
ABSTRACT
Engraftment failure is a rare but life-threatening complication of haematopoietic stem cell transplantation (HSCT) and treatment of this condition is often challenging. This case report describes a patient with acute myeloid leukaemia and engraftment failure after unrelated donor allogeneic stem cell transplantation. Rescue treatment with granulocyte-colony stimulating factor and reinfusion of autologous 'back-up' stem cells failed, but transplantation of haploidentical donor stem cells following a fludarabine and antithymocyte globulin (ATG)-based conditioning regimen resulted in haematological reconstitution and long-term disease-free survival. The use of haploidentical donor stem cell transplantation as salvage therapy after engraftment failure in adult patients has not, to the authors' knowledge, been previously reported. Additionally, a review of the relevant literature is presented. This case report and literature review suggest that reinfusion of cryopreserved 'back-up' haematopoietic stem cells is a safe and effective salvage therapy for engraftment failure after allogeneic HSCT. Haploidentical donor stem cell transplantation after a fludarabine and ATG-based conditioning regimen could provide effective second-line therapy in adult patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Haplotypes
/
Leukemia, Myeloid, Acute
/
Salvage Therapy
/
Hematopoietic Stem Cell Transplantation
/
Graft Rejection
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
J Int Med Res
Year:
2011
Document type:
Article
Affiliation country: