Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients.
J Helminthol
; 86(3): 339-47, 2012 Sep.
Article
in En
| MEDLINE
| ID: mdl-21838960
ABSTRACT
Initial clinical trials using Trichuris suis eggs (TSO) in autoimmune diseases such as inflammatory bowel disease, revealed a striking suppressive effect on the autoimmune response. Here, we analysed the effect of TSO therapy on the course of multiple sclerosis (MS), as a Th1/Th17-associated autoimmune disease. Different immunological parameters in four patients with secondary progressive MS were surveyed during a 6-month therapy with TSO, focusing on the modulation of T-cell Th1-Th2 balance as well as on the innate immune response. We are able to show a slight downregulation of the Th1-associated cytokine pattern, especially relevant in interleukin (IL)-2 (P < 0.05 after 2 months of therapy), with a temporary increase of Th2-associated cytokines such as IL-4. Furthermore, mild eosinophily and changes in CD4+ and CD8+T cells and natural killer (NK) CD56 bright cell numbers were observed. The findings observed in this group of patients suggest that TSO therapy has a moderate immunomodulatory impact in MS.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trichuris
/
Th2 Cells
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Th1 Cells
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Multiple Sclerosis, Relapsing-Remitting
/
Immunotherapy
Limits:
Adult
/
Animals
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
J Helminthol
Year:
2012
Document type:
Article
Affiliation country: