Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.
Bioorg Med Chem Lett
; 21(20): 6154-60, 2011 Oct 15.
Article
in En
| MEDLINE
| ID: mdl-21890356
ABSTRACT
To further explore the optimum placement of the acid moiety in conformationally constrained analogs of GW 4064 1a, a series of stilbene replacements were prepared. The benzothiophene 1f and the indole 1g display the optimal orientation of the carboxylate for enhanced FXR agonist potency.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stilbenes
/
Receptors, Cytoplasmic and Nuclear
/
Isoxazoles
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2011
Document type:
Article
Affiliation country: