Primary hyperparathyroidism - is vitamin D supplementation safe?

ABSTRACT

BACKGROUND: Vitamin D deficiency is commonly seen in patients with primary hyperparathyroidism. However, there is a widespread reluctance to provide vitamin D supplementation to this group of patients. OBJECTIVE: This article examines the relationship between vitamin D deficiency and primary hyperparathyroidism and the effects of vitamin D supplementation. CONCLUSION: Vitamin D deficiency exacerbates primary hyperparathyroidism and vice versa. With care, vitamin D supplementation can safely be given to selected patients with asymptomatic primary hyperparathyroidism and is suggested before deciding on medical or surgical management. Monitoring serum calcium concentration and urinary calcium excretion is recommended while achieving vitamin D repletion.