Antistaphylococcal activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic.
Antimicrob Agents Chemother
; 56(3): 1584-7, 2012 Mar.
Article
in En
| MEDLINE
| ID: mdl-22203585
ABSTRACT
TD-1792 is a new multivalent glycopeptide-cephalosporin antibiotic with potent activity against Gram-positive bacteria. The in vitro activity of TD-1792 was tested against 527 Staphylococcus aureus isolates, including multidrug-resistant isolates. TD-1792 was highly active against methicillin-susceptible S. aureus (MIC(90), 0.015 µg/ml), methicillin-resistant S. aureus, and heterogeneous vancomycin-intermediate S. aureus (MIC(90), 0.03 µg/ml). Time-kill studies demonstrated the potent bactericidal activity of TD-1792 at concentrations of ≤ 0.12 µg/ml. A postantibiotic effect of >2 h was observed after exposure to TD-1792.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glycopeptides
/
Cephalosporins
/
Methicillin-Resistant Staphylococcus aureus
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2012
Document type:
Article
Affiliation country: