The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis.
Genes Dev
; 26(1): 6-10, 2012 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-22215805
ABSTRACT
Differentiation of multipotent stem cells occurs through the highly coordinated control of gene expression. Repressor element 1 (RE1) silencing transcription factor (REST), a master transcriptional regulator in neuronal stem cells, restricts neuronal gene expression. REST activity is context-dependent and is modified by its cofactors, such as Ctdsp2. In this issue of Genes & Development, Dill and colleagues (pp. 25-30) report on the microRNA-mediated regulation of neural differentiation. Interestingly, this microRNA is post-transcriptionally regulated and modulates expression of its host gene, ctdsp2.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Differentiation
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Phosphoprotein Phosphatases
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Gene Expression Regulation, Developmental
/
Zebrafish Proteins
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MicroRNAs
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Neurons
Limits:
Animals
Language:
En
Journal:
Genes Dev
Journal subject:
BIOLOGIA MOLECULAR
Year:
2012
Document type:
Article
Affiliation country: