Innate response activator B cells protect against microbial sepsis.
Science
; 335(6068): 597-601, 2012 Feb 03.
Article
in En
| MEDLINE
| ID: mdl-22245738
ABSTRACT
Recognition and clearance of a bacterial infection are a fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytokine storm, and precipitates septic shock. These observations enrich our understanding of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new treatment avenues for infectious diseases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peritonitis
/
Granulocyte-Macrophage Colony-Stimulating Factor
/
B-Lymphocyte Subsets
/
Sepsis
/
Escherichia coli Infections
/
Immunity, Innate
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Science
Year:
2012
Document type:
Article
Affiliation country: