Joint tenderness and swelling in biologic-treated inflammatory arthritis patients - a tricky trade off?
Int J Clin Pract
; 66(2): 128-31, 2012 Feb.
Article
in En
| MEDLINE
| ID: mdl-22257038
ABSTRACT
OBJECTIVE:
To compare the pattern of joint responses in patients with rheumatoid arthritis and psoriatic arthritis treated with TNF inhibitor (TNFi) therapy.METHODS:
A total of 182 PsA/Rheumatoid arthritis (RA) patients attending the rheumatology unit of a tertiary referral centre in Ireland were recruited and prospectively followed up by the attendant rheumatologists. Clinical progress of the patients was noted at baseline and 6 months after starting TNFi therapy.RESULTS:
A total of 114 RA and 68 PsA patients were assessed; 20% of the patients had one of either tender joints or swollen joints after 6 months of therapy. Rheumatoid arthritis patients had a significantly higher proportion of non-tender swollen joints compared with PsA patients, whereas PsA patients had a higher proportion of tender non-swollen joints (p < 0.05).CONCLUSION:
Residual joint swelling was found more commonly in RA patients than in PsA patients following TNFi therapy, whereas residual tender joints occurred more frequently in PsA; this may reflect enthesiopathy or periostitis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Rheumatoid
/
Arthritis, Psoriatic
/
Tumor Necrosis Factor-alpha
/
Arthralgia
/
Antirheumatic Agents
/
Edema
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Clin Pract
Journal subject:
MEDICINA
Year:
2012
Document type:
Article
Affiliation country: