Insulin-mimicking anti-idiotypic antibodies in development of spontaneous autoimmune diabetes in BB/E rats.
Diabetes
; 39(12): 1467-71, 1990 Dec.
Article
in En
| MEDLINE
| ID: mdl-2245874
ABSTRACT
BB/E rats spontaneously develop a form of autoimmune diabetes resembling insulin-dependent diabetes mellitus (IDDM) in humans. IDDM results from central destruction of the insulin-producing beta-cells of the pancreatic islets. Herein, we report that the outbreak of IDDM in BB/E rats is preceded by the spontaneous development of an anti-idiotypic antibody to a particular antibody to insulin made by the rats. This anti-idiotype, designated anti-DM-id, behaves as an antibody to the insulin-hormone receptor. Thus, a spontaneous anti-idiotypic antibody network whose products can affect the peripheral utilization of insulin seems to accompany the central destruction of beta-cells in developing IDDM.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Rats, Inbred BB
/
Antibodies, Anti-Idiotypic
/
Diabetes Mellitus, Experimental
/
Insulin
Limits:
Animals
Language:
En
Journal:
Diabetes
Year:
1990
Document type:
Article
Affiliation country: