Smooth muscle in tissue remodeling and hyper-reactivity: airways and arteries.
Pulm Pharmacol Ther
; 26(1): 13-23, 2013 Feb.
Article
in En
| MEDLINE
| ID: mdl-22561160
ABSTRACT
Smooth muscle comprises a key functional component of both the airways and their supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host of breathing-associated pathologies such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. These diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. This review will focus on the contribution of airway or vascular smooth dysfunction to common airway diseases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Pulmonary Disease, Chronic Obstructive
/
Hypertension, Pulmonary
/
Muscle, Smooth
Limits:
Animals
/
Humans
Language:
En
Journal:
Pulm Pharmacol Ther
Journal subject:
FARMACOLOGIA
Year:
2013
Document type:
Article
Affiliation country: