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Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
Safina, Brian S; Baker, Stewart; Baumgardner, Matt; Blaney, Paul M; Chan, Bryan K; Chen, Yung-Hsiang; Cartwright, Matthew W; Castanedo, Georgette; Chabot, Christine; Cheguillaume, Arnaud J; Goldsmith, Paul; Goldstein, David M; Goyal, Bindu; Hancox, Timothy; Handa, Raj K; Iyer, Pravin S; Kaur, Jasmit; Kondru, Rama; Kenny, Jane R; Krintel, Sussie L; Li, Jun; Lesnick, John; Lucas, Matthew C; Lewis, Cristina; Mukadam, Sophie; Murray, Jeremy; Nadin, Alan J; Nonomiya, Jim; Padilla, Fernando; Palmer, Wylie S; Pang, Jodie; Pegg, Neil; Price, Steve; Reif, Karin; Salphati, Laurent; Savy, Pascal A; Seward, Eileen M; Shuttleworth, Stephen; Sohal, Sukhjit; Sweeney, Zachary K; Tay, Suzanne; Tivitmahaisoon, Parcharee; Waszkowycz, Bohdan; Wei, Binqing; Yue, Qin; Zhang, Chenghong; Sutherlin, Daniel P.
Affiliation
  • Safina BS; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. bsafina@gene.com
J Med Chem ; 55(12): 5887-900, 2012 Jun 28.
Article in En | MEDLINE | ID: mdl-22626259
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Enzyme Inhibitors / Drug Discovery / Cytochrome P-450 CYP3A Inhibitors / Phosphoinositide-3 Kinase Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Enzyme Inhibitors / Drug Discovery / Cytochrome P-450 CYP3A Inhibitors / Phosphoinositide-3 Kinase Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: Country of publication: