Ring expansion of cyclic ß-amino alcohols induced by diethylaminosulfur trifluoride: synthesis of cyclic amines with a tertiary fluorine at C3.
J Org Chem
; 77(14): 6087-99, 2012 Jul 20.
Article
in En
| MEDLINE
| ID: mdl-22686336
ABSTRACT
As the replacement of a hydrogen atom by a fluorine atom in a compound can have an important impact on its biological properties, the development of methods allowing the introduction of a fluorine atom is of great importance. The scope and limitations of the ring expansion of cyclic 2-hydroxymethyl amines induced by diethylaminosulfur trifluoride (DAST) to produce cyclic ß-fluoro amines was studied as well as the enantioselectivity of the process.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diethylamines
/
Fluorine
/
Amines
/
Amino Alcohols
Language:
En
Journal:
J Org Chem
Year:
2012
Document type:
Article
Affiliation country: