Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells.
Pak J Pharm Sci
; 25(3): 645-50, 2012 Jul.
Article
in En
| MEDLINE
| ID: mdl-22713955
ABSTRACT
The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancer-origin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test (BSLT), the present results suggest the potential use of the B-serum sub-fractions in cancer treatment.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast
/
Hevea
/
Cell Proliferation
/
Epithelial Cells
/
Latex
Limits:
Animals
/
Female
/
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Pak J Pharm Sci
Journal subject:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Year:
2012
Document type:
Article
Affiliation country: