[Impacts of HIV-1 resistance mutations associated with nucleoside reverse transcriptase inhibitors on viral fitness].
Bing Du Xue Bao
; 28(3): 291-6, 2012 May.
Article
in Zh
| MEDLINE
| ID: mdl-22764534
ABSTRACT
Nucleoside reverse transcriptase inhibitors which act as a major component of highly active antiretroviral therapy regimens are widely used in treatment of Acquired Immune Deficiency Syndrome. However, the emergence of drug-resistant variants of HIV-1 severely limits the effectiveness of these drugs. Many drug resistance mutations confer a fitness cost, which can be partially overcome by compensatory mutations or other molecular mechanisms. This review focuses on the impacts of resistance mutations emerging during treatment with nucleoside reverse transcriptase inhibitors on viral fitness, and inter actions between these mutations.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
HIV-1
/
Reverse Transcriptase Inhibitors
/
Drug Resistance, Viral
/
HIV Reverse Transcriptase
Type of study:
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Bing Du Xue Bao
Journal subject:
VIROLOGIA
Year:
2012
Document type:
Article
Affiliation country: