Cytomegalovirus antibody status at 17-18 weeks of gestation and pre-eclampsia: a case-control study of pregnant women in Norway.
BJOG
; 119(11): 1316-23, 2012 Oct.
Article
in En
| MEDLINE
| ID: mdl-22804776
ABSTRACT
OBJECTIVE:
To assess the association between maternal cytomegalovirus (CMV) antibodies in mid-pregnancy and pre-eclampsia.DESIGN:
Nested case-control study.SETTING:
Pregnancies registered in the Norwegian Mother and Child Cohort Study (MoBa) a large population-based pregnancy cohort (1999-2006). SAMPLE A cohort of 1500 women with pre-eclampsia and 1000 healthy pregnant women.METHODS:
Plasma samples and pregnancy-related information were provided by the MoBa. Antibody status (CMV IgG and CMV IgM) and levels (CMV IgG) at 17-18 weeks of gestation were determined by enzyme-linked immunosorbent assay (ELISA). MAIN OUTCOMEMEASURE:
A diagnosis of pre-eclampsia, as defined in the Medical Birth Registry of Norway.RESULTS:
There was no evidence of an effect of CMV IgG seropositivity on the likelihood of developing pre-eclampsia, and CMV IgG antibody levels among women who were seropositive did not differ between groups. Adjusted for maternal age, parity and smoking, the odds ratio for pre-eclampsia in women seropositive for CMV IgG was 0.89 (95% CI 0.74-1.05; P = 0.17). The proportions of women who were seropositive for IgM did not differ between women with pre-eclampsia and women who were healthy (P = 0.98). Among nulliparous women, the proportion of women who were seropositive for CMV IgG was slightly lower among women with pre-eclampsia (53.5%) than among healthy women (59.8%) (P = 0.03). Subgroup analyses were performed for women with early or late onset pre-eclampsia, with preterm delivery and/or with neonates that were small for gestational age, but antibody status did not differ between pre-eclampsia subtypes and controls.CONCLUSIONS:
The presence of maternal antibodies to CMV was not associated with pre-eclampsia in our study. The results suggest that CMV infection is unlikely to be a major cause of pre-eclampsia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pre-Eclampsia
/
Pregnancy Complications, Infectious
/
Cytomegalovirus Infections
/
Cytomegalovirus
/
Antibodies, Viral
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Europa
Language:
En
Journal:
BJOG
Journal subject:
GINECOLOGIA
/
OBSTETRICIA
Year:
2012
Document type:
Article
Affiliation country: