The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population.
Mol Med Rep
; 6(4): 894-6, 2012 Oct.
Article
in En
| MEDLINE
| ID: mdl-22825546
ABSTRACT
Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93.14%) carried the AA wild-type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Interleukin-10
/
Polymorphism, Single Nucleotide
/
Asian People
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Mol Med Rep
Year:
2012
Document type:
Article