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A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity.
Ling, Xiang; Cao, Shousong; Cheng, Qiuying; Keefe, James T; Rustum, Youcef M; Li, Fengzhi.
Affiliation
  • Ling X; Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA.
PLoS One ; 7(9): e45571, 2012.
Article in En | MEDLINE | ID: mdl-23029106
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-bcl-2 / Benzodioxoles / Inhibitor of Apoptosis Proteins / X-Linked Inhibitor of Apoptosis Protein / Indolizines / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-bcl-2 / Benzodioxoles / Inhibitor of Apoptosis Proteins / X-Linked Inhibitor of Apoptosis Protein / Indolizines / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: Country of publication: