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Impact of BCR-ABL mutations on response to dasatinib after imatinib failure in elderly patients with chronic-phase chronic myeloid leukemia.
Tiribelli, Mario; Latagliata, Roberto; Luciano, Luigiana; Castagnetti, Fausto; Gozzini, Antonella; Cambrin, Giovanna Rege; Annunziata, Mario; Stagno, Fabio; Pregno, Patrizia; Albano, Francesco; Abruzzese, Elisabetta; Musto, Pellegrino; Montefusco, Enrico; Fava, Carmen; Fanin, Renato; Pane, Fabrizio; Rosti, Gianantonio; Breccia, Massimo; Alimena, Giuliana; Vigneri, Paolo.
Affiliation
  • Tiribelli M; Division of Hematology and Bone Marrow Transplantation, Azienda Ospedialiero-Universitaria, Piazzale S. M. Misericordia 15, Udine, Italy. mario.tiribelli@uniud.it
Ann Hematol ; 92(2): 179-83, 2013 Jan.
Article in En | MEDLINE | ID: mdl-23053188
ABSTRACT
To assess the impact of BCR-ABL kinase domain mutations on dasatinib response in elderly chronic myeloid leukemia (CML) patients, we analyzed the outcome of 76 individuals aged >60 affected by imatinib-resistant chronic-phase CML. We found that 36 cases (47 %) displayed mutations before dasatinib. Compared to non-mutated patients, subjects with point mutations had a worse response to dasatinib, with significantly lower rates of complete cytogenetic response (57 vs 32 %), higher percentage of primary resistance (16/36 vs 6/40) and a trend towards a shorter median event-free survival. Our data suggest that, in elderly patients, detection of BCR-ABL mutations negatively affects response to dasatinib.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyrimidines / Thiazoles / Leukemia, Myeloid, Chronic-Phase / Fusion Proteins, bcr-abl / Point Mutation / Drug Resistance, Neoplasm / Mutation, Missense / Protein Kinase Inhibitors / Antineoplastic Agents Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Ann Hematol Journal subject: HEMATOLOGIA Year: 2013 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyrimidines / Thiazoles / Leukemia, Myeloid, Chronic-Phase / Fusion Proteins, bcr-abl / Point Mutation / Drug Resistance, Neoplasm / Mutation, Missense / Protein Kinase Inhibitors / Antineoplastic Agents Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Ann Hematol Journal subject: HEMATOLOGIA Year: 2013 Document type: Article Affiliation country: