Your browser doesn't support javascript.
loading
Cross neutralisation of Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms.
Leong, Poh Kuan; Tan, Nget Hong; Fung, Shin Yee; Sim, Si Mui.
Affiliation
  • Leong PK; Department of Pharmacology, CENAR, University of Malaya, Kuala Lumpur, Malaysia.
Trans R Soc Trop Med Hyg ; 106(12): 731-7, 2012 Dec.
Article in En | MEDLINE | ID: mdl-23062608
ABSTRACT
Cross neutralisation of venoms by antivenom raised against closely-related species has been well documented. The spectrum of paraspecific protection of antivenom raised against Asiatic Naja and Bungarus (krait) venoms, however, has not been fully investigated. In this study, we examined the cross neutralisation of venoms from common Southeast Asian cobras and kraits by two widely used polyvalent antivenoms produced in India Vins Polyvalent Antivenom (VPAV) and Bharat Polyvalent Antivenom (BPAV), using both in vitro and in vivo mouse protection assays. BPAV was only moderately effective against venoms of N. kaouthia (Thailand) and N. sumatrana, and either very weakly effective or totally ineffective against the other cobra and krait venoms. VPAV, on the other hand, neutralised effectively all the Southeast Asian Naja venoms tested, as well as N. naja, B. candidus and Ophiophagus hannah venoms, but the potency ranges from effective to weakly effective. In an in vivo rodent model, VPAV also neutralised the lethality of venoms from Asiatic Naja and B. candidus. In anesthetised rat studies, both antivenoms effectively protected against the N. kaouthia venom-induced cardio-respiratory depressant and neuromuscular blocking effects. Overall, our results suggest that VPAV could be used as alternative antivenom for the treatment of elapid envenomation in Southeast Asian regions including Malaysia, Thailand and certain regions of Indonesia.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Snake Bites / Antivenins / Elapidae / Elapid Venoms Limits: Animals Country/Region as subject: Asia Language: En Journal: Trans R Soc Trop Med Hyg Year: 2012 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Snake Bites / Antivenins / Elapidae / Elapid Venoms Limits: Animals Country/Region as subject: Asia Language: En Journal: Trans R Soc Trop Med Hyg Year: 2012 Document type: Article Affiliation country: