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5-HT3 receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells.
Yasuda, M; Kato, S; Yamanaka, N; Iimori, M; Matsumoto, K; Utsumi, D; Kitahara, Y; Amagase, K; Horie, S; Takeuchi, K.
Affiliation
  • Yasuda M; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Br J Pharmacol ; 168(6): 1388-400, 2013 Mar.
Article in En | MEDLINE | ID: mdl-23072534
Subject(s)
Antimetabolites, Antineoplastic/adverse effects; Apoptosis/drug effects; Fluorouracil/adverse effects; Immunosuppressive Agents/adverse effects; Intestinal Mucosa/drug effects; Mucositis/prevention & control; Serotonin 5-HT3 Receptor Antagonists/therapeutic use; Animals; Antimetabolites, Antineoplastic/therapeutic use; Apoptosis Regulatory Proteins/antagonists & inhibitors; Apoptosis Regulatory Proteins/genetics; Apoptosis Regulatory Proteins/metabolism; Benzimidazoles/administration & dosage; Benzimidazoles/adverse effects; Benzimidazoles/therapeutic use; Colonic Neoplasms/drug therapy; Cytokines/genetics; Cytokines/metabolism; Diarrhea/etiology; Diarrhea/prevention & control; Dose-Response Relationship, Drug; Drug Interactions; Fluorouracil/antagonists & inhibitors; Fluorouracil/therapeutic use; Gastrointestinal Agents/administration & dosage; Gastrointestinal Agents/therapeutic use; Gene Expression Regulation/drug effects; Immunosuppressive Agents/antagonists & inhibitors; Immunosuppressive Agents/therapeutic use; Intestinal Mucosa/immunology; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Male; Mice; Mice, Inbred C57BL; Mucositis/chemically induced; Mucositis/metabolism; Mucositis/pathology; Ondansetron/adverse effects; Ondansetron/therapeutic use; Serotonin 5-HT3 Receptor Agonists/adverse effects; Serotonin 5-HT3 Receptor Agonists/therapeutic use; Serotonin 5-HT3 Receptor Antagonists/administration & dosage; Serotonin 5-HT3 Receptor Antagonists/adverse effects
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Mucositis / Serotonin 5-HT3 Receptor Antagonists / Fluorouracil / Immunosuppressive Agents / Intestinal Mucosa / Antimetabolites, Antineoplastic Type of study: Etiology_studies Language: En Journal: Br J Pharmacol Year: 2013 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Mucositis / Serotonin 5-HT3 Receptor Antagonists / Fluorouracil / Immunosuppressive Agents / Intestinal Mucosa / Antimetabolites, Antineoplastic Type of study: Etiology_studies Language: En Journal: Br J Pharmacol Year: 2013 Document type: Article Affiliation country: Country of publication: