In vitro activity of telavancin and occurrence of vancomycin heteroresistance in isolates from patients enrolled in phase 3 clinical trials of hospital-acquired pneumonia.
Diagn Microbiol Infect Dis
; 74(4): 429-31, 2012 Dec.
Article
in En
| MEDLINE
| ID: mdl-23083812
ABSTRACT
In phase 3 studies of the efficacy of telavancin for the treatment of hospital-acquired pneumonia, 704 Gram-positive and 627 Gram-negative aerobic bacterial pathogens were obtained at baseline from 1503 patients. The majority of Gram-positive isolates (n = 650 [92%]) were Staphylococcus aureus, of which 410 (63%) were methicillin-resistant (MRSA). Of the MRSA isolates, 9.5% were identified as heterogeneous vancomycin-intermediate S. aureus. All Gram-positive isolates were inhibited by ≤1 µg/mL of telavancin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Staphylococcal Infections
/
Staphylococcus aureus
/
Carrier State
/
Vancomycin Resistance
/
Aminoglycosides
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Diagn Microbiol Infect Dis
Year:
2012
Document type:
Article
Affiliation country: