New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Nat Genet
; 45(1): 76-82, 2013 Jan.
Article
in En
| MEDLINE
| ID: mdl-23202124
ABSTRACT
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Birth Weight
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Body Height
/
Quantitative Trait Loci
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Fetal Development
/
Genetic Linkage
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Adult
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Female
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Humans
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Male
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Newborn
Language:
En
Journal:
Nat Genet
Journal subject:
GENETICA MEDICA
Year:
2013
Document type:
Article
Affiliation country: